Biodistribution and Target Engagement Assays for Oligonucleotide Therapeutics
Accelevir specializes in siRNA biodistribution assays, ASO target engagement testing, and siRNA immunogenicity profiling to accelerate regulatory submissions. Our GLP oligonucleotide testing platform integrates mRNA knockdown assays, cytokine profiling ASO, and low-input siRNA workflows for multi-species studies.
Challenges in siRNA & ASO Development
- Target engagement confirmation: Verifying mRNA knockdown in target tissues.
- Biodistribution tracking: Determining tissue-specific uptake and persistence.
- Innate immune activation: Assessing inflammatory responses to oligos or delivery systems.
- Sample limitations: Small, precious specimens from preclinical models or patients.
How Accelevir Supports Oligo Programs
- Target Engagement Assays
- qPCR/dPCR to quantify mRNA suppression in tissue and cell samples.
- Allele-specific assays for precise knockdown measurement.
- Biodistribution Studies
- Multiplex dPCR for oligo detection in diverse tissue panels.
- GLP-compliant multi-species workflows.
- Immunogenicity Testing
- Cytokine multiplex panels for innate immune activation.
- Flow cytometry for immune cell activation profiles.
- Low-Input & Longitudinal Monitoring
- Optimized for small-volume, time-course samples.
Why Partner with Accelevir
- Custom assay development aligned to oligo platform needs.
- Cross-functional molecular and immune monitoring from one team.
- CLIA-certified, GLP-ready laboratory.