News Room

News, publications, and program milestones from Accelevir Diagnostics, spanning HIV, oncology, and gene therapy bioanalytical research and partnerships.

Recent Publications

Publications

HIV-specific and resistant CAR T cells promote control of HIV replication in people with HIV

Res Sq [Preprint]. · 2026 Jul

MVA.HIVconsvX vaccination-evoked T cell expansion inversely associates with age in people with HIV-1 on antiretroviral therapy

J Clin Invest. · 2026 May

Expansion of stemlike HIV-specific CD8(+) T cells and limited viral epitope diversity characterize durable posttreatment control of HIV

Sci Transl Med. · 2026 Apr

Allograft Rejection and the Latent HIV Reservoir in Kidney Transplant Recipients with HIV

J Infect Dis. · 2026 Mar

Interleukin-2 is a potent latency reversal agent in people with treated HIV-1

Sci Adv.· 2025 Dec

Comparison of manual and automated ultrasensitive assays for residual HIV-1 in plasma from individuals on suppressive antiretroviral therapy

J Clin Microbiol. · 2025 Dec

Retinol Binding Protein 4 reactivates latent HIV-1 by triggering canonical NF-κB, JAK/STAT5 and JNK signalling

Signal Transduct Target Ther.· 2025 Oct

Intact and Defective HIV Provirus Changes During Antiretroviral Therapy in People Treated During Acute or Chronic HIV Infection or as HIV Controllers

Open Forum Infect Dis.· 2025 Sep

BCL-2 Inhibition via Venetoclax at ART Initiation Induces Long-Term Reduction of the Intact SIV Reservoir

Res Sq [Preprint].· 2025 Jul

Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts

Nat Commun.· 2025 May

Ex vivo and in vivo HIV-1 latency reversal by “Mukungulu,” a protein kinase C-activating African medicinal plant extract

mBio.· 2025 May

A First-in-Class Dual Degrader of Bcl-2/Bcl-xL Reverses HIV Latency and Minimizes Ex Vivo Reservoirs from Patients

Int J Mol Sci.· 2025 Mar

Galectin 9 Levels as a Potential Predictor of Intact HIV Reservoir Decay

J Infect Dis.· 2025 Feb

SIV Env RhmAbs + N-803 at ART initiation prolongs viral decay without disrupting reservoir establishment in SIV-infected infant macaques

PLoS Pathog.· 2025 Jan

Single-cell analyses reveal that monocyte gene expression profiles influence HIV-1 reservoir size in acutely treated cohorts

bioRxiv[Preprint].· 2024 Nov

Rapid biphasic decay of intact and defective HIV DNA reservoir during acute treated HIV disease

Nat Commun.· 2024 Nov

The immunogenicity of an HIV-1 Gag conserved element DNA vaccine in people with HIV and receiving antiretroviral therapy

AIDS.· 2024 Jun

HIV-1 Remission after Allogeneic Hematopoietic-Cell Transplantation

N Engl J Med.· 2024 Feb

HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV

J Infect Dis.· 2023 Nov

The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy

J Clin Invest.· 2023 Sep

Current HIV/SIV Reservoir Assays for Preclinical and Clinical Applications: Recommendations from the Experts 2022 NIAID Workshop Summary

AIDS Res Hum Retroviruses.· 2023 Jun

Varied Patterns of Decay of Intact Human Immunodeficiency Virus Type 1 Proviruses Over 2 Decades of Antiretroviral Therapy

J Infect Dis.· 2023 Jun

The effect of induction immunosuppression for kidney transplant on the latent HIV reservoir

JCI Insight.· 2022 Nov

Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods

PLoS Pathog.· 2022 Sep

Evaluation of HIV-1 reservoir size and broadly neutralizing antibody susceptibility in acute antiretroviral therapy-treated individuals

AIDS.· 2022 Feb

Single center, open label dose escalating trial evaluating once weekly oral ixazomib in ART-suppressed, HIV positive adults and effects on HIV reservoir size in vivo

EClinical Medicine.· 2021 Nov

Similar Frequency and Inducibility of Intact Human Immunodeficiency Virus-1 Proviruses in Blood and Lymph Nodes

J Infect Dis.· 2021 Jul

The TLR7 agonist vesatolimod induced a modest delay in viral rebound in HIV controllers after cessation of antiretroviral therapy

Sci Transl Med.· 2021 Jun

Vesatolimod, a Toll-like Receptor 7 Agonist, Induces Immune Activation in Virally Suppressed Adults Living With Human Immunodeficiency Virus-1

Clin Infect Dis.· 2021 Jun

Nonstructured Treatment Interruptions Are Associated With Higher Human Immunodeficiency Virus Reservoir Size Measured by Intact Proviral DNA Assay in People Who Inject Drugs

J Infect Dis.· 2021 Jun

Selective Decay of Intact HIV-1 Proviral DNA on Antiretroviral Therapy

J Infect Dis.· 2021 Feb

Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy

Clin Infect Dis.· 2021 Feb

Shared Mechanisms Govern HIV Transcriptional Suppression in Circulating CD103(+) and Gut CD4(+) T Cells

J Virol.· 2020 Dec

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

Nature.· 2020 Sep

Intact proviral DNA assay analysis of large cohorts of people with HIV provides a benchmark for the frequency and composition of persistent proviral DNA

Proc Natl Acad Sci U S A.· 2020 Aug

Elite suppressors have low frequencies of intact HIV-1 proviral DNA

AIDS.· 2020 Mar

Differential decay of intact and defective proviral DNA in HIV-1-infected individuals on suppressive antiretroviral therapy

JCI Insight.· 2020 Feb

The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections

Cell Host Microbe.· 2019 Jul

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses

Nature.· 2019 Feb