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In a Phase 2 or Phase 3 trial, you might have twenty different clinical sites collecting blood. If Site A uses a different centrifuge speed than Site B, or if Site C leaves the blood on the bench for four hours longer than Site D, your downstream data will be incredibly noisy. Site-to-Site Variability is […]
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One of the most frustrating scenarios in bioanalytics is the “High Background” plate. You run a functional assay, and your negative control wells are full of non-specific activity. Is it the assay? Is it the reagents? More often than not, it is the cryopreservation protocol. Through our PBMC Processing & Functional Validation Services at Accelevir, […]
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At Accelevir, we focus on ultra-rare target detection and have become hyper-vigilant about incoming PBMC Quality which includes viability, recovery and Flow based immuno-profiling. As expected we find that PBMC quality is one of the most critical elements of end-point readouts and triage decisions for clinical trial design and outcome measurements. Sponsors frequently discover—too late—that […]
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